学术带头人

    陈松林

    陈松林，男，博士，研究员。现任中国水产科学研究院黄海水产研究所水产生物技术与基因组研究室主任，海洋科学与技术试点国家实验室海洋渔业科学与食物产出过程功能实验室副主任。兼任中国水产科学研究院水产生物技术领域首席科学家，中国水产学会水产生物技术专业委员会主任委员，山东省海洋渔业生物技术与遗传育种重点实验室主任，山东省泰山学者攀登计划专家；兼任国际刊物Sci Reports和Marine Biotechnology编委，《水产学报》副主编等职务。

    主要研究方向包括鱼类基因组学、基因资源发掘和分子育种、性别决定和性别控制、细胞培养和种质冷冻保存等。先后主持国家863、973、公益性行业（农业）科研专项、国家自然科学基金重点项目、山东省良种工程等项目40多项。领衔完成了半滑舌鳎和牙鲆等6种海水鱼类全基因组解析，发现半滑舌鳎雌性特异分子标记和雄性决定基因，揭示鲆鳎鱼类性别决定和变态发育的分子机制；建立了鲆鳎鱼类基因资源发掘和分子育种的技术体系，建立了鲆鳎鱼类基因组选择育种技术和基因组编辑技术；发明半滑舌鳎高雌性苗种制种技术；发明鱼类精子冷冻保存实用化方法，建立30多种海淡水鱼类精子冷冻库；发明鱼类胚胎玻璃化冷冻保存技术，突破海水鱼胚胎冷冻保存技术难关；建立23个鱼类细胞系；育成牙鲆新品种2个和罗非鱼新品种1个。获国家技术发明二等奖2项（排名1）、国家科技进步奖二等奖1项（排名2）。以第一完成人获授权发明专利34项。发表论文420余篇，其中，第一和通讯作者SCI论文190多篇，包括Nature Genetics论文2篇，Genome Research论文1篇。主编出版“鱼类基因组学和基因组育种技术”及“鱼类性别控制和细胞工程育种”等中英文专著5部。获第十二届光华工程科技奖、全国首届创新争先奖状、第四届中华农业英才奖、第三届中国青年科技奖、国家百千万人才工程第一二层次人选、农业部和山东省有突出贡献中青年专家、山东省泰山学者攀登计划专家等20多项荣誉称号。

    部分代表性论文清单：

    1. Qian Zhou, Zhencheng Su, Yangzhen Li, Yang Liu, Lei Wang, Sheng Lu, Shuangyan Wang,Tian Gan, Feng Liu, Xun Zhou, Min Wei, Guangjian Liu* , Songlin Chen* 2019 Genome-wide association mapping and gene expression analyses reveal genetic mechanisms of disease resistance variations in Cynoglossus semilaevis. Frontiers in Genetics. 10:1167（1-12）

    2. Qian Zhou#, Haoyang Gao#, Yong Zhang , Guangyi Fan, Hao Xu, Jieming Zhai, Wenteng Xu, Zhangfan Chen, He Zhang, Wensheng Li, Weiming Li*, Haoran Lin*, Songlin CHEN*2019A chromosome-level genome assemblyof thegiant grouper,Epinephelus lanceolatusprovides insights into its innate immunity and fast growth. Molecular Ecol Res., 19(5):1322-1332

    3. 陈松林，徐文腾，刘洋2019鱼类基因组研究十年回顾与展望。水产学报，43（1）：1-14

    4. Yang Liu#, Sheng Lu#, Feng Liu, Changwei Shao, Qian Zhou, Na Wang, Yangzhen Li, Yingming Yang, Yingping Zhang, Hejun Sun, Weiwei Zheng, Songlin Chen* 2018 Genomic selection usingBayesCπ and GBLUP for resistance againstEdwardsiella tardain Japanese flounder (Paralichthys olivaceus).Mar Biotech., 20:559-565.

    5. Zhongkai Cui#, Yun Liu#, Wenwen Wang, Qian Wang, Ning Zhang, Fan Lin, Na Wang, Changwei Shao, Zhongdian Dong, Yangzhen Li, Yingming Yang, Mengzhu Hu, Hailong Li, Fengtao Gao, Zhanfei Wei, Liang Meng, Yang Liu, Min Wei, Ying Zhu, Hua Guo, Christopher H.K. Cheng*,ManfredSchartl*, Songlin Chen* 2017Genome editing revealsdmrt1as an essential male sex-determining gene in Chinese tongue sole (Cynoglossus semilaevis).Sci Reports,7:42213 | DOI: 10.1038/srep42213..

    6. Changwei Shao#, Baolong Bao#, Zhiyuan Xie#, Xinye Chen#, Bo Li#, Xiaodong Jia#, Qiulin Yao, Guillermo Ortí, Wenhui Li, Xihong Li, Kristin Hamre, Juan Xu, Lei Wang, Fangyuan Chen, Yongsheng Tian, Alex M. Schreiber Na Wang, Fen Wei, Jilin Zhang, Zhongdian Dong, Lei Gao, Junwei Gai, Takashi Sakamoto, Sudong Mo, Wenjun Chen, Qiong Shi, Hui Li,Yunji Xiu, Yangzhen Li, Wenteng Xu, Zhiyi Shi,Guojie Zhang, Deborah M Power*, Qingyin Wang*, Manfred Schartl*, Songlin Chen* 2017The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry. Nature Genetics, 49(1):119-124. DOI.10.1038/ng.3732

    7. 陈松林，邵长伟，徐鹏 2016水产生物技术发展战略研究。中国工程科学，18（3）：49-56

    8. Changwei Shao#, Yongchao Niu#, Rastas Pasi, Yang Liu, Zhiyuan Xie, Hengde Li, Lei Wang, Yong Jiang, Shuaishuai Tai, Yongsheng Tian, Takashi Sakamoto*, Songlin Chen* 2015Genome-Wide SNP Identification for the Construction of a High-Resolution Genetic Map of Japanese Flounder (Paralichthys olivaceus) Applied to QTL Mapping ofVibrio anguillarumDisease Resistance and Comparative Genomic Analysis. DNA Research.22(2), 161–170.

    9. Changwei Shao#, Qiye Li#, Songlin Chen#*, Pei Zhang, Jinmin Lian, Qiaomu Hu, Bing Sun, Lijun Jin, Shanshan Liu, Zongji Wang, Hongmei Zhao, Zonghui Jin, Zhuo Liang, Yangzhen Li, Qiumei Zheng, Yong Zhang, Jun Wang, Guojie Zhang* 2014 Epigenetic modification and inheritance in sexual reversal of fish. Genome Research, 2014, 24:604-615

    10. Songlin Chen#*, Guojie Zhang#, Changwei Shao#, Quanfei Huang#, Geng Liu#, Pei Zhang#, Wentao Song, Na An, Domitille Chalopin3, Jean-Nicolas Volff3, Yunhan Hong4, Qiye Li2, Zhenxia Sha1, Heling Zhou2, Mingshu Xie1, Qiulin Yu2, Yang Liu5, Hui Xiang6, Na Wang1, Kui Wu2, Changgeng Yang1, Qian Zhou2, Xiaolin Liao1, Linfeng Yang2, Qiaomu Hu1, Jilin Zhang2, Liang Meng1, Lijun Jin2, Yongsheng Tian1, Jinmin Lian2, Jingfeng Yang1, Guidong Miao1, Shanshan Liu1, Zhuo Liang1, Fang Yan1, Yangzhen Li1, Bin Sun1, Hong Zhang1, Jing Zhang1, Ying Zhu1, Min Du1, Yongwei Zhao1, Manfred Schartl*, Qisheng Tang* & Jun Wang*. 2014 Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to benthic lifestyle. Nature Genetics, 2014，46（3）：253-260.

    11. Na Wang, Xian-Li Wang, Chang-Geng Yang,Yu-Xi Zhang,TianZhi Wang, Song-Lin Chen* 2014Molecular cloning and multifunctional characterization of GRIM-19 (Gene associated with Retinoid-Interferon-induced Mortality 19) homologue from turbot (Scophthalmus maximus).Dev Comp Immunol,43(1) :96-105

    12. Chen Song-Lin, Ji Xiang-Shan, Shao Chang-Wei, Li Wen-Long, Yang Jing-Feng, Liang Zuo, Liao Xiao-Lin, Xu Gen-Bo, Xu Ying, Song Wen-Tao 2012Induction of mito-gynogenetic diploidsandidentificationof WW super-female using sex-specific SSR markersinhalf-smooth tongue sole (Cynoglossus semilaevis)。Mar Biotechnol, 14(1) :120-128.

    13. Chen Song-lin, Li Jing, Deng Si-ping, Tian Yong-Sheng, Wang Qing-yin, Zhuang Zhimeng, Sha Zhenxia, Xu Jianyong 2007 Isolation of female-specific AFLP markers and molecular identification of genetic sex in half-smooth tongue sole (Cynoglossus semilaevis). Mar Biotech, 9(2):273-280.

    14. Chen Song-Lin, Li Wei, Meng Liang, Sha Zhen-Xia, Wang Zhi-Jian, Ren Guo-Cheng 2007 Molecular cloning and expression analysis of a hepcidin antimicrobial peptide gene from turbot (Scophthalmus maximus). Fish Shell Immunol，22:172-181.

    15. Chen SL, Xu MY, Ji XS, Yu GC, Liu Y. 2005 Cloning, characterization and expression analysis of hepcidin gene from red sea bream (Chrysophrys major). Antimicrob. Agents Chemo., 49(4):1608-1612.

    16. Chen S.L., Tian Y.S. 2005. Cryopreservation of flounder embryos by vitrification. Theriogenology, 63(4):1207-1219.

    17. Chen S.L., Xu M.Y., Hu S.N., Li L. 2004. Analysis of immune-relevant genes expressed in red sea bream spleen. Aquaculture, 240:115-130.

    18. Chen S.L., Ren G.C., Sha Z.X., Shi C.Y. 2004 Establishment of a continuous embryonic cell line from flounder (Paralichthys olivaceus) for virus isolation. Disease of Aquatic Organism, 60:241-246. (SCI收录)

    19. Chen S.L，Ji X.S., Yu G.C., Tian Y.S., Sha Z.X.2004. Cryopreservation of spermatozoa from turbot (Scophthalmus maximus) and application to large scale fertilization. Aquaculture, 236:547-556

    20. Chen, S.L, Sha ZX, Ye HQ. 2003 Establishment of a pluripotent embryonic cell line from sea perch blastula embryo. Aquaculture, 218:141-151

      专著清单：

    21. Han-Ping Wang, Francesc Piferrer, Song-Lin Chen， edited《Sex Control in Aquaculture》, Volume 1 and 2. Wiley Blackwell, 2019，UK

    22. 陈松林主编《鱼类基因组学与基因组育种技术》。科学出版社，2017，北京.

    23. 陈松林主编《鱼类性别控制与细胞工程育种》。科学出版社，2013年，北京。

    24. 陈松林，秦启伟主编《鱼类细胞培养理论与技术》。科学出版社，2011年，北京。

    陈松林主著《鱼类精子和胚胎冷冻保存理论与技术》。农业出版社，2007年，北京。